​Selected Clinical Research Trials Being Conducted at Joslin Diabetes Center​​

Auto-Calibration Study

  • Auto-Calibration and Shaped Insulin Delivery

    ​This study aims to collect high quality glycemic information from persons with type 1 diabetes using meal challenges.

Type 1
Glucose Control

Bydureon Study

  • Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients with Type 1 Diabetes

    This study is designed to test if the drug Bydureon® (exenatide-ER) improves blood glucose control in patients with type 1 diabetes.

Type 1
Glucose Control

CIRT Study

  • CIRT: Cardiovascular Inflammation Reduction Trial

    The purpose of this study if reducing inflammation with low-dose methotrexate, a very common anti-inflammatory drug, can lower the risk of having future heart attacks, strokes, or dying from heart disease.

At Risk
Heart

Dairy Study

  • Effect of Consumption of Dairy Products on Glycemic Control, Body Weight and Cardiovascular Risk Factors in Patients with Type 2 Diabetes

    The purpose of this study is to compare the effects of low fat and full fat dairy products on blood sugar control in people with type 2 diabetes.

Type 2
Glucose Control

Exercise Training Study

  • Investigation of Exercise Training Induced Myokines and Adipokines in Humans

    The purpose of this study is to study the effects of aerobic exercise training on circulating proteins secreted from fat and muscle tissue in a healthy population.

Healthy Volunteer

EXTEND

  • Preserving Beta-cell Function with Tocilizumab in New Onset Type 1 Diabetes

    This study is designed to test if the drug tocilizumab can help preserve or delay destruction of remaining beta cells in people recently diagnosed with type 1 diabetes.

Glucose Control
Type 1

Family Management

  • Improving Family Management and Glycemic Control in Youth <8 Years Old with Type 1 Diabetes

    This study will explore parental attitudes toward diabetes management in young children.

Type 1
Glucose Control

FIDELIO-DKD

  • Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

    The purpose of this study is to demonstrate whether, in addition to standard of care (SoC), finerenone is superior to placebo in delaying the progression of kidney disease.

Kidney
Type 2

FIGARO-DKD

  • Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

    The purpose of this study is to demonstrate whether finerenone is superior to placebo in delaying the time to first occurrence of cardiovascular mortality in subjects with Type 2 Diabetes Mellitus and clinical diagnosis of diabetic kidney disease.

Kidney
Type 2

Glucagon Pump Study

  • Glucagon Pump for Post-Gastric Bypass Hypoglycemia

    ​The purpose of this study is to test if a continuous glucose sensor which is linked to a computer and a pump that can provide a low does of glucagon can help prevent hypoglycemia (low blood sugar) in individuals who have post-gastric bypass hypoglycemia syndrome.

Glucose Control

INSPIRE Study

  • Psychosocial Aspects of Artificial Pancreas Research

    This study will explore attitudes toward diabetes technology and automated insulin delivery.

Type 1
Technology

International Diabetes Closed Loop Trial

  • Clinical Acceptance of the Artificial Pancreas: The International Diabetes Closed Loop (iDCL) Trial: Research Pilot Study

    We are looking for volunteers to help us find out more about usability of a proposed automated insulin delivery system named inControl.

Type 1
Technology

Joslin Heart Study

  • Metabolic Pathways of Increased Cardiovascular Risk in Type 2 Diabetes

    ​The purpose of this study is to examine the mechanisms through with genetic factors may predispose people with diabetes to cardiovascular (heart) disease.

Type 2
Heart

MAiD

  • Monitoring Autoimmunity in Diabetes

    The purpose of the "Monitoring Autoimmunity in Diabetes" study is to look at changes in the body that may occur with the development of type 1 diabetes.

Type 1

Perceptions

  • Patient and Parent Perceptions of Hypertension and Hyperlipidemia Management and Diabetes Complications

    This study will explore parent and youth attitudes toward cardiovascular risk factors such as high cholesterol or blood pressure and diabetes complications.

Type 1
Heart

T1D Exchange

  • The T1D Exchange Type 1 Diabetes Network-Pediatric, Adolescent, and Young Adult Section

    The Type 1 Diabetes (T1D) Exchange is a nationwide registry collecting information about children and adults with type 1 diabetes.

Type 1

TrialNet

  • TrialNet Natural History Study for the Prevention of Type 1 Diabetes

    The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes.

Type 1
At Risk

Not Recruiting


Betaine Study

  • Metabolic Effects of Betaine Supplementation

    In this clinical research study we are evaluating whether supplementation of a naturally occurring component found in beets and other vegetables and grains reduces diabetes risk.

At Risk
Heart

DPPOS

  • Diabetes Prevention Program Outcomes Study

    The purpose of this study is to look at the effects of the study interventions in the DPP on the development of type 2 diabetes as well as diabetes related health problems and cancer diagnosis over a longer period of time.

Type 2

EDIC

  • Epidemiology of Diabetes Intervention and Complications

    The purpose of this study is to study the development of the major long-term complications of type 1 diabetes among the volunteers who participated in the Diabetes Control and Complication Trial (DCCT) and the first twelve years of the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

Type 1

Look AHEAD - E

  • ACTION FOR HEALTH IN DIABETES – Extension Study

    ​The purpose of this study is to understand the long-term effects of weight change on overall health in the cohort of the original Look AHEAD study.

Type 2

Medalist Study

  • 50-Year Medalist Study

    The purpose of this study is to document the presence of eye, nerve and kidney complications related to diabetes, as well as to examine DNA and substances in the blood and urine of people with diabetes for 50 years or more.

Type 1

PERL Study

  • A Multi-Center Clinical Trial of Allopurinol to Prevent Renal Function (GFR) Loss in Type 1 Diabetes

    The purpose of this study is to find out whether a medication called allopurinol can prevent kidney problems, in particular the loss of kidney function, in people with type 1 diabetes.

Type 1

TODAY - 2

  • Treatment Options for Type 2 Diabetes in Adolescents and Youth 2 Phase 2

    The purpose of TODAY 2 Phase 2 is to find out if the drug treatment or lifestyle program participants received during the TODAY Study has any long- term effect on blood sugar control or the medical complications of diabetes, like heart or kidney disease.

Type 2