Joslin Clinical Research


Auto-Calibration Study

Auto-Calibration and Shaped Insulin Delivery

Description:

​This study aims to collect high quality glycemic information from persons with type 1 diabetes using meal challenges.

Mathematical modeling and numerical minimization techniques will be used to calibrate insulin pumps and to derive optimized personalized insulin delivery schedules, thereby minimizing postprandial blood glucose and overall hypoglycemia risk.

This study involves a series of 4-hour mixed meal challenges with frequently sampled intravenous blood glucose monitoring.

Recruitment:

  • ​18 years of age or older.
  • Use of insulin pump for at least 3 months prior to the study.
  • HbA1c<9.0%
  • No history of diabetic ketoacidosis in the prior 6 months.
  • No known allergy to milk.
  • Not pregnant or planning pregnancy.

Contact:

Email TrialNet@joslin.harvard.edu or call (888) 813-8669

CHS(#2015-33)

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Betaine Study

Metabolic Effects of Betaine Supplementation

Description:

In this clinical research study we are evaluating whether supplementation of a naturally occurring component found in beets and other vegetables and grains reduces diabetes risk. The product we are studying is a modified amino acid that is important in several metabolic pathways and lower in patients with diabetes and cardiovascular risk factors.

This study involves:

  • A glucose tolerance test, commonly used to diagnose type 2 diabetes and if prediabetic will be randomized (like the flip of a coin) to receive the supplement or a placebo.
  • Measurements of insulin sensitivity, liver fat, and blood vessel function will occur before and after 3 months of supplementation, requiring two days and the overnight stay at the beggining and again at the end of the study with two additional morning visits during the study.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

CHS(#2013-10)

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Brain Activation and Balance Study

Diabetic or Alzheimer’s Effects on Brain Activation and Standing Balance

Description:

This study seeks to determine the effects of type 2 diabetes mellitus OR Alzheimer's disease on blood flow velocity and levels of oxygen in the brain, and how these changes influence one's balance when standing with and without a secondary task.

This study involves one study visit lasting up to 3.5 hours at Hebrew SeniorLife (1200 Centre Street). Blood flow velocity, oxygenated hemoglobin, postural control/standing balance, heart rate, and blood pressure will be recorded during sitting, standing, and standing while completing secondary tasks. Cognitive and balance assessments will also be conducted.

Monetary compensation for visits. Transportation, if needed and free parking.

Recruitment:

You may be eligible if you are an older adult 70 years or older with:

  • type 2 diabetes OR
  • Alzheimer's disease
  • Able to stand continuously for at least 5 minutes without assistance such as a walker or a cane

Contact:

Azizah Jor'dan at email azizahjordan@hsl.harvard.edu or call 857-364-6339

CHS(#IRB-2015-28)

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Dairy Study

Effect of Consumption of Dairy Products on Glycemic Control, Body Weight and Cardiovascular Risk Factors in Patients with Type 2 Diabetes

Description:

The purpose of this study is to compare the effects of low fat and full fat dairy products on blood sugar control in people with type 2 diabetes.

The study involves:

  •  3 visits to Joslin Diabetes Center over 24 weeks
  • 5 follow-up phone calls
  • Blood tests and body fat measurements
  • Meeting with a dietitian
  • Keeping a food log

Monetary compensation, parking validation and reimbursement for dairy product purchases will be provided for eligible study participants.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Osama Hamdy

CHS(#2016-04)

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DPPOS

Diabetes Prevention Program Outcomes Study

Description:

The purpose of this study is to look at the effects of the study interventions in the DPP on the development of type 2 diabetes as well as diabetes related health problems and cancer diagnosis over a longer period of time.

Recruitment: This study is not currently recruiting.

​This study is no longer recruiting.

Contact:

​Principal Investigator: Dr. Edward Horton

CHS(#02-29)

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EDIC

Epidemiology of Diabetes Intervention and Complications

Description:

The purpose of this study is to study the development of the major long-term complications of type 1 diabetes among the volunteers who participated in the Diabetes Control and Complication Trial (DCCT) and the first twelve years of the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

Recruitment: This study is not currently recruiting.

​This study is no longer recruiting.

Contact:

​Principal Investigator: Dr. Lloyd Paul Aiello

CHS(#94-04)

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Exercise Regulation of Human Adipose Tissue

Exercise Regulation of Human Adipose Tissue

Description:

​The purpose of this study is to better understand the effect of exercise training on your adipose (fat) tissue. This information will be used in the design of future studies to treat diabetes.

The study involves:

  • Having a phone interview to discuss the study and see if you are eligible.
  • Attending a 3.5 hour screening visit with an Oral Glucose Tolerance Test.
  • Attending multiple visits at Joslin for an exercise assessment and fat tissue sampling.
  • 10 weeks of guided exercise training with at least 2 weekly sessions at Joslin.
  • Assessment of your fitness on a cycle before and after exercise training.
  • Blood tests and surveys.
  • Tracking your exercise via activity tracker.
  • Monitoring of your blood glucose during the study by a Joslin physician.

**Monetary compensation and parking validation will be provided for eligible study participants**

Recruitment:

​Eligibility:

  • Age 30-50 years
  • Exercising < 3 times per week
  • With or without a diagnosis of Type 2 diabetes

Contact:

Jeffrey Richard at (617)309-4378 or exercise.research@joslin.harvard.edu

CHS(#2016-33)

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Exercise Training Study

Investigation of Exercise Training Induced Myokines and Adipokines in Humans

Description:

The purpose of this study is to study the effects of aerobic exercise training on circulating proteins secreted from fat and muscle tissue in a healthy population.

The study involves:

  • At least 24 visits to Joslin Diabetes Center over 13 weeks.
  • 10 weeks of guided exercise training with at least 2 weekly sessions at Joslin.
  • Oral Glucose Tolerance Test before and after exercise training.
  • Assessment of your fitness on a cycle before and after exercise training.
  • Blood tests and survery.
  • Tracking your exercise via activity tracker.

*Monetary compensation and parking validation will be provided for eligible study participants.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

CHS(#2016-34)

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EXTEND

Preserving Beta-cell Function with Tocilizumab in New Onset Type 1 Diabetes

Description:

This study is designed to test if the drug tocilizumab can help preserve or delay destruction of remaining beta cells in people recently diagnosed with type 1 diabetes. There is evidence that giving medicines to affect the immune system, such as tocilizumab, may stop, delay, or decrease the destruction of beta cells, if given soon after diabetes is diagnosed. This may result in better glucose control.

​This study involves:

  • Tocilizumab or a placebo given via intravenous infusions monthly over a 6-month period.
  • Follow-up for an additional 18 months.
  • Periodic visits including blood draws and mixed meal tolerance tests.
  • Intensive diabetes management.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Jason Gaglia

CHS(#2015-08)

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Family Management

Improving Family Management and Glycemic Control in Youth <8 Years Old with Type 1 Diabetes

Description:

This study will explore parental attitudes toward diabetes management in young children. 

The study involves:

  • A one-on-one interview or focus group. The study visit can take place on the same day as your routine diabetes visit and will take about 30-60 minutes.
  • Parents will complete surveys in clinic or at home, which will take approximately 30 minutes. 

The study will provide a parking voucher on the day of the study. Participants will also receive compensation for their time and effort.

Recruitment: This study is not currently recruiting.

This study is not currently recruiting.

Contact:

Principal Investigator: Dr. Lori Laffel

CHS(#2015-12)

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FIDELIO-DKD

Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

Description:

The purpose of this study is to demonstrate whether, in addition to standard of care (SoC), finerenone is superior to placebo in delaying the progression of kidney disease.

This study involves:

  • Taking the study drug, finerenone, or inactive medication (placebo).
  • 16 study visits in a span of 2 years. After the first month, the visits will be every 4 months.
  • Duration of study will be approximately 2 years.

Monetary compensation and parking validation will be provided for eligible study participants.

Recruitment:

  • ​Men or women 18 years or older.
  • Type 2 Diabetes Mellitus (T2DM).
  • Clinical diagnosis of Diabetic Kidney Disease.
  • Receiving treatment for high blood pressure.

Contact:

Taylor Pierce at 617-309-4616 or taylor.pierce@joslin.harvard.edu

CHS(#2015-42)

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FIGARO-DKD

Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

Description:

The purpose of this study is to demonstrate whether finerenone is superior to placebo in delaying the time to first occurrence of cardiovascular mortality in subjects with Type 2 Diabetes Mellitus and clinical diagnosis of diabetic kidney disease.

This study involves:

  • Taking the study drug finerenone or inactive medication (placebo).
  • 16 study visits in a span of 2 years. After the first month the visits will be every 4 months. 
  • Duration of study will be approximately 2 years.

Monetary compensation and parking validation will be provided for eligible study participants.

Recruitment:

  • ​Men or women 18 years or older
  • Type 2 Diabetes Mellitus (T2DM)
  • Clinical diagnosis of Diabetic Kidney Disease
  • Receiving treatment for high blood pressure

Contact:

Taylor Pierce at 617-309-4616 or taylor.pierce@joslin.harvard.edu

CHS(#2016-15)

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Glucagon Pump Study

Closed-Loop Glucagon Pump for Post-Gastric Bypass Hypoglycemia

Description:

​The purpose of this study is to test if a continuous glucose sensor linked to a computer and a pump can provide a low dose of glucagon to prevent hypoglycemia after a liquid meal in individuals who have hypoglycemia after gastric bypass.

This study involves:

  • Up to 5 visits to Joslin Diabetes Center over 4 weeks
  • A mixed meal tolerance test and blood draws
  • Wearing a continuous glucose monitor and a fitness tracker
  • Keeping a food log and blood sugar log

Parking or taxi will be reimbursed on the days of your study visits. In addition, you will receive a subject stipend for completion of the first mixed meal study (visit 3) and another stipend for participation and completion of study visit 5. 

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Mary Elizabeth Patti

CHS(#2016-27)

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Glucose Monitoring Study

Determining Efficacy of Continuous Glucose Monitoring to Reduce Hypoglycemia and Improve Safety after Gastric Surgery

Description:

The purpose of this study is to test if a continuous glucose monitor (CGM) can detect and help prevent hypoglycemia (low blood sugar) in individuals who have post-bariatric surgery hypoglycemia syndrome.

This study involves:

  • 3 to 5 visits to Joslin Diabetes Center over 4 weeks
  • Wearing a continuous glucose monitor and fitness tracker
  • Keeping a log of blood sugar levels, hypoglycemic symptoms, and treatment of symptoms
  • Keeping a food and activity log

Recruitment:

​You may qualify to participate if you are:

  • A male or female diagnosed with ongoing post-bariatric or post-gastric surgery hypoglycemia with prior episodes of neuroglycopenia (low blood sugars with neurological symptoms).
  • Ages 18-65 years.

Study staff will compensate you for the cost of parking or taxi services. At the completion of the study, you will be able to keep the continuous glucose monitor system, including receiver (good for indefinite use) and transmitter (duration of use 6 months).

Contact:

Lauren Richardson at (617) 309-4463 or hypoglycemiastudy@joslin.harvard.edu

CHS(#2017-27)

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Hypoglycemia and the Gut Microbiome

Hypoglycemia and the Gut Microbiome

Description:

​The purpose of this study is to find out if patterns of microbiome composition (bacteria in your stool) are related to how glucose levels change after a meal in patients with hypoglycemia (low blood sugar).

This study involves:

  • 2 visits to Joslin Diabetes Center over 2 weeks
  • Wearing a continuous glucose monitor and a fitness tracker
  • Providing a stool sample
  • Keeping a log of blood sugar levels, hypoglycemic events, and treatment of hypoglycemia symptoms

The study will compensate you for the cost of parking or taxi services for each visit.

Recruitment:

  • Males or females diagnosed with ongoing post-bariatric, post-gastric surgery or other forms of postprandial hypoglycemia with prior episodes of neuroglycopenia
  • Age 18-65 years of age, inclusive, at screening.
  • Willingness to provide informed consent and follow all study procedures, including attending all scheduled visits.

Contact:

​Lauren Richardson at (617) 309-4463 or hypoglycemiastudy@joslin.harvard.edu

CHS(#2017-28)

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INSPIRE Study

Psychosocial Aspects of Artificial Pancreas Research

Description:

This study will explore attitudes toward diabetes technology and automated insulin delivery.

Participation involves:

  • one-on-one interview or focus group discussing attitudes toward diabetes technologies. The study visit can take place on the same day as your routine diabetes visit and will take about 30-60 minutes.

The study will provide a parking voucher on the day of the study visit. Participants will also receive compensation for their time and effort.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Lori Laffel

CHS(#2015-05)

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International Diabetes Closed Loop Trial

Clinical Acceptance of the Artificial Pancreas: The International Diabetes Closed Loop (iDCL) Trial: Research Pilot Study

Description:

We are looking for volunteers to help us find out more about usability of a proposed automated insulin delivery system named inControl.

This study will include:

  • Up to 5 visits to the clinic over the period of 2-4 weeks.
  • 2 week period of at home use of inControl device with daily contact.
  • Vitals and A1c measurement.
  • Questionnaire.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Lori Laffel

CHS(#2016-20)

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JEST Study

Are you a man with type 2 diabetes? Are you trying to improve your diabetes control?

Description:

Our goal is to better understand how diabetes, glycemic control, and fitness may affect reproductive health and epigenetic factors in sperm. We are especially interested in studying men before and after improvements in diabetes control and/or weight loss.

The study will involve:
- Brief physical exam.
- Blood test.
- Sperm samples.
- 2 or 3 visits to Joslin Diabetes Center over 3 months.
- Weekly phone calls to review blood glucose levels.

If your diabetes is uncontrolled (A1c > 7.5%), you will receive oral diabetes medications, blood glucose test strips and meter, and nutrition advice at no cost for the study period.

*Parking vouchers and compensation are provided to all participants.*

Recruitment:

Are you…
- Male
- Age 18-65 years

Do you have any of the following conditions?
- Type 2 diabetes
- Pre-diabetes
- Overweight (BMI >25)
- A1c > 7.5%

Contact:

CHS(#2015-40)

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Joslin Heart Study

Metabolic Pathways of Increased Cardiovascular Risk in Type 2 Diabetes

Description:

​The purpose of this study is to examine the mechanisms through with genetic factors may predispose people with diabetes to cardiovascular (heart) disease. Understanding how these genes work may help scientists find new ways to prevent cardiovascular diseases in people with diabetes for the future.

​The study involves:

  • One visit to the Joslin Diabetes Center, during which participants will undergo blood tests (fasting blood glucose, kidney function tests, cholesterol), urine tests, and an ECG.
  • A CT scan to measure the amount of calcium in the coronary arteries. This will be performed at the Brigham and Women's hospital right after the visit at the Joslin or on another day up to three months after the study visit.
  • All study related procedures and tests are at no charge.
  • All information will be held strictly confidential.

Monetary compensation and parking validation will be provided for eligible study participants.

Recruitment:

​We are seeking participants who:

  • have been diagnosed with Type 2 Diabetes for 2-10 years.
  • were diagnosed between the ages of 30-65.
  • are currently between the ages of 35-70.

Contact:

Kyla Murray or Caroline Bulcao Souza at 1-866-622-3885 or email joslinheartstudy@joslin.harvard.edu

CHS(#2016-12)

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Look AHEAD - E

ACTION FOR HEALTH IN DIABETES – Extension Study

Description:

​The purpose of this study is to understand the long-term effects of weight change on overall health in the cohort of the original Look AHEAD study.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting.

Contact:

Principal Investigator: Dr. Edward Horton

CHS(#2016-08)

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MAiD

Monitoring Autoimmunity in Diabetes

Description:

The purpose of the "Monitoring Autoimmunity in Diabetes" study is to look at changes in the body that may occur with the development of type 1 diabetes. The samples taken as part of this study will be used to look at various genes, cells, and factors, which may be associated with type 1 diabetes and the immune system. These will be used to study why some people are at higher risk for developing diabetes and what happens to the immune system with the development of the disease.

Participants may also qualify and be asked to participate in a separate clinical study that uses a novel magnetic resonance imaging (MRI) technique to noninvasively image insulitis (the destructive process in the pancreas that leads to loss of insulin production).

Recruitment: This study is not currently recruiting.

This study is no longer recruiting.

Contact:

Principal Investigator: Dr. Jason Gaglia

CHS(#2010-27)

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Meal Replacement Study

Effect of Meal Replacement Shakes on Blood Sugar Control in Adults with Type 2 Diabetes

Description:

​The purpose of this study is to determine the effect of meal replacement shakes on blood sugar control in people who have type 2 diabetes and are overweight. Participants will be randomized to either continue with their normal diet or to replace breakfast and a daily snack with nutritional shakes.

This study involves:

  • 3 visits to Joslin Diabetes Center over 14 days
  • Wearing a continuous glucose monitor
  • Keeping a daily tracking log
  • 1 follow-up phone call (approximately 10 minutes)

Monetary compensation and parking validation will be provided for eligible study participants, in addition to meal replacement shakes.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Osama Hamdy

CHS(#2017-02)

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Medalist Study

50-Year Medalist Study

Description:

The purpose of this study is to document the presence of eye, nerve and kidney complications related to diabetes, as well as to examine DNA and substances in the blood and urine of people with diabetes for 50 years or more. This is to identify factors which may protect from large and small vessel complications, and potentially lead to protection from aging related diseases.

Recruitment: This study is not currently recruiting.

​This study is not currently recruiting.

Contact:

​Principal Investigator: Dr. George King

CHS(#04-19)

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Metabolic Health and Sperm

Impact of metabolic health on sperm epigenetic marks in humans

Description:

​The purpose of this study is to determine whether a man's metabolic health, including diabetes and body weight, can affect signals in his sperm which affect how genes are turned on or off. (These are called epigenetic factors.)  These signals may be important for the health of his offspring.

The study involves:

  • 2 visits to Joslin, 3 months apart
  • Phone calls before each visit for scheduling
  • Blood test, body fat measurements, and physical exam during each study visit
  • Self-collection of sperm samples at each of the 2 visits (materials provided)
  • If required, a medication (sildenafil) will be provided to make it easier to collect the sperm sample.

Monetary compensation and parking validation are provided for eligible study participants.

Recruitment:

  • Male, age 18 to 65
  • If diagnosed with diabetes, hemoglobin A1c over 7%
  • Overweight or obese (body mass index over 25 kg/m2)
  • Non-smoker

Contact:

​Lauren Richardson at lauren.richardson@joslin.harvard.edu or (617) 309-4463.

CHS(#2015-40)

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On-Body Study

Patient and Parent Preferences for an On-body Automated Insulin Delivery System

Description:

​Cross-sectional study assessing patient and parent preferences for an automated, on-body insulin delivery system, using semi-structured interviews and validated surveys in order to assist in the design of such a system.

Duration: 1 visit lasting less than 1 hour

Monetary compensation available.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

CHS(#2018-05)

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Perceptions

Patient and Parent Perceptions of Hypertension and Hyperlipidemia Management and Diabetes Complications

Description:

This study will explore parent and youth attitudes toward cardiovascular risk factors such as high cholesterol or blood pressure and diabetes complications.

Participation involves:

  • one interview or focus group for approximately 60-90 minutes. Interviews can be on the same day as routine diabetes visits and will add an extra 60 minutes to the clinic day.

The study will provide a parking voucher on the day of the interview or focus group. Participating teens and parents will also receive compensation for their time and effort.​

Recruitment: This study is not currently recruiting.

This study is longer recruiting.

Contact:

Principal Investigator: Dr. Michelle Katz

CHS(#2015-30)

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PERL Study

A Multi-Center Clinical Trial of Allopurinol to Prevent Renal Function (GFR) Loss in Type 1 Diabetes

Description:

The purpose of this study is to find out whether a medication called allopurinol can prevent kidney problems, in particular the loss of kidney function, in people with type 1 diabetes.

Recruitment: This study is not currently recruiting.

​This study is no longer recruiting.

Contact:

​Principal Investigator: Dr. Allesandro Doria

CHS(#2013-19)

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PIONEER 8 Trial

Efficacy and Safety of Oral Semaglutide versus Placebo in Subjects with Type 2 Diabetes Mellitus Treated with Insulin

Description:

​The purpose of this trial is to study effects of an investigational drug, called Semaglutide (not FDA approved yet) that may help control blood sugar levels. This study will compare Semaglutide (in pill form) to inactive medicine (placebo) over approximately 12 months.

The study involves:

  • 10 visits to Joslin Diabetes Center over 52 weeks
  • 7 follow-up phone calls
  • Blood tests and physical examination
  • Electrocardiogram (measure electric activity of your heart)
  • Recording your blood glucose values
  • Parking validation, in addition to financial compensation

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Osama Hamdy

CHS(#2016-30)

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Precision Study

Evaluating the accuracy of the LabPatch Continuous Glucose Monitoring system (CGM)

Description:

​This study is evaluating the accuracy of an investigational device (not FDA approved yet) called LabPatch Continuous Glucose Monitor by comparing it to a laboratory glucose analyser called YSI, and 2 commercial glucose meters.

The study involves:

  • Two visits to Joslin Diabetes Center: a 1-2 hours screening visit and a 6 hours study visit
  • Placement of the LabPatch device on your arm using an adhesive tape
  • Insertion of an IV line through which all blood samples will be collected during the study visit
  • Measuring your blood sugar levels, throughout your second study visit
  • Breakfast and lunch will be provided
  • Parking validation, in addition to financial compensation

Recruitment:

You may be eligible if you are:

  • Aged 18-75 years
  • Have type 1 or 2 diabetes for at least 3 months
  • Being treated with insulin

Contact:

​Shaheen Tomah, MD at (617) 309-4144 or Shaheen.Tomah@joslin.harvard.edu

CHS(#2016-31)

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SENCE Study

Strategies to Enhance New CGM use in Early Childhood (SENCE)

Description:

​A clinical trial to find out how well the continuous glucose monitor works in children less than 8 years old with T1D and whether an added program for parents/guardians can improve comfort with using the CGM and improve blood glucose control.

This study will include:

  • 8 clinic visits and up to 6 phonecalls over a 12 month period
  • Use of a Continuous Glucose Monitor (CGM)
  • Review of diabetes management and dowload of blood glucose meter
  • Physical exams, vitals, and A1c measurements
  • Questionnaires

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Lori Laffel

CHS(#2016-28)

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T1D Exchange

The T1D Exchange Type 1 Diabetes Network-Pediatric, Adolescent, and Young Adult Section

Description:

The Type 1 Diabetes (T1D) Exchange is a nationwide registry collecting information about children and adults with type 1 diabetes. The purpose of the registry is to gather information about people with type 1 diabetes to better understand the natural course of type 1 diabetes and the effectiveness of current treatments.

Participation in the registry involves:

  • completion of a questionnaire about medical and family history including diabetes diagnosis, treatment, and laboratory test results.
  • Annual updates of information.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Sanjeev Mehta

CHS(#2011-01)

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T1GER Study

SIMPONI® to Arrest Beta-Cell Loss in Type 1 Diabetes

Description:

This study aims to determine if the drug SIMPONI® (golimumab) can preserve beta-cell function in children and young adults with newly diagnosed type 1 diabetes.

The T1GER study is investigating the effect of treatment with golimumab, a TNF alpha-blocker, on beta-cell function in children, adolescents, and young adults with newly diagnosed type 1 diabetes. This study will also evaluate the safety and tolerability of the study drug in individuals with type 1 diabetes.

Participation in the study includes a screening visit and 13 clinical site visits over approximately two years.

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Jason Gaglia

CHS(#2017-06)

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The CIAO Study

Insulin dosing practices in persons with diabetes on multiple daily injections

Description:

​This study uses an electronic dose-recording device to examine dosing in individuals on multiple daily insulin injections.

This study includes:

  • 2 visits at Joslin
  • Access to new insulin pen cap technology
  • Monetary compensation for visits and parking

Recruitment:

  • 18-35 or 65+ years old
  • Take at least 2 daily insulin injections for your diabetes

Contact:

Christine Slyne at Christine.slyne@joslin.harvard.edu or 617-309-4683

CHS(#2015-47)

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The IGNITE Study

Promoting Lifestyle Changes with Mobile Health Technologies for Overweight or Obese Older Adults with Type 2 diabetes – Feasibility & Acceptability Study

Description:

​This study examines the effect that mobile health technology has on promoting lifestyle changes in adults with type 2 diabetes.

This study includes:

  • 3 study visits and 5 weight loss intervention classes at Joslin Diabetes Center over the course of 3 months
  • Monetary compensation for visits and parking

Recruitment:

  • Have type 2 diabetes
  • Are 65+ years old
  • Take insulin or oral medication
  • Have wireless Internet at home

Contact:

Jordan Greenberg at Jordan.greenberg@joslin.harvard.edu or (617)309-4682

CHS(#2016-13)

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The TANGO Study

Technological Advances in Glucose Management in Older Adults

Description:

​This study assesses a new technology that aids the communication of health information amongst patients, family members/caregivers, and providers. The study is also looking to determine if this technology is a helpful tool in diabetes management.

This study includes:

  • 6-8 visits (both virtual and Joslin Clinical Research Center visits) over 6-12 months
  • Monetary compensation for visits and parking

Recruitment:

  • 65 years of age and older
  • Type 1 Diabetes
  • Either take multiple insulin injections (≥3 injection/s day) or use an insulin pump (Medtronic, Insulet)

Contact:

​Tara MacNeil at tara.macneil@joslin.harvard.edu or 617-309-3449

Christine Slyne at Christine.slyne@joslin.harvard.edu or 617-309-4683

CHS(#2016-29)

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TODAY - 2

Treatment Options for Type 2 Diabetes in Adolescents and Youth 2 Phase 2

Description:

The purpose of TODAY 2 Phase 2 is to find out if the drug treatment or lifestyle program participants received during the TODAY Study has any long- term effect on blood sugar control or the medical complications of diabetes, like heart or kidney disease.

Recruitment: This study is not currently recruiting.

This study is not currently recruiting.

Contact:

Principal Investigator: Dr. Lori Laffel

CHS(#2014-31)

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T-Rex Study

Exploratory Study of CLBS03 in Children with Recent Onset T1D

Description:

​This study aims to assess if one's own expanded regulatory T cells can rebalance the immune system, decreasing the attack on the insulin producing cells in type 1 diabetes.

Regulatory T cells (Tregs) are a type of immune cell that maintains tolerance to self-antigens, preventing autoimmune disease. In this study, blood will be collected from children recently diagnosed with type 1 diabetes (T1D) and used as a source to grow Tregs in the lab. These lab-grown Tregs will be returned to the participant to try and rebalance the immune system, decreasing the autoimmune attack on the insulin producing beta cells. Participants will receive either one of two different doses of Tregs or a placebo infusion.

This study involves:

  • 2-year commitment
  • 12 periodic visits including blood draws and mixed meal tolerance tests
  • Intensive diabetes management

Recruitment: This study is not currently recruiting.

This study is no longer recruiting participants.

Contact:

Principal Investigator: Dr. Jason Gaglia

CHS(#2017-01)

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TrialNet

TrialNet Natural History Study for the Prevention of Type 1 Diabetes

Description:

The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes. 

The study involves:

  •  A single blood test.  People who test positive will be eligible for further testing and may be eligible to participate in prevention trials.

Recruitment:

  • Parents, children, & siblings, ages 1-45 of people with type 1 diabetes.
  • Cousins, grandchildren, nieces, & nephews, ages 1-20 of people with type 1 diabetes.

Contact:

Email TrialNet@joslin.harvard.edu or call 888-813-8669

CHS(#03-33)

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