About Joslin | Patient Care | Supporting Joslin
Obesity-induced inflammation plays an important role in the development of insulin resistance. Recent studies suggest that immune cells in the local tissues, specifically adipose tissues, regulate obesity-induced inflammation. My lab has also shown that obesity activates pro-inflammatory adipose tissue immune cells, including natural killer (NK) cells and adipose tissue macrophages (ATMs), while simultaneously suppressing anti-inflammatory immune cells such as regulator T cells (Tregs). My lab continues to explore the molecular and cellular mechanisms underlying how obesity controls the immunological functions of adipose tissue immune cells. My lab also studies how these adipose tissue immune cells, in particular ATMs, Tregs and NK cells, cross-regulate each other to control obesity-induced inflammation and how this cross-regulation then mediates the development of obesity-induced insulin resistance.
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